He joined Manchester United's youth team on leaving school in the summer of 1952. He became a first-team member at right-half during the 1955-56 season, ousting Jeff Whitefoot to play alongside Duncan Edwards. He finished the season with a Football League First Division title medal. He collected another league championship medal the following season, and also
He made 108 first-team appearances for United, scoring two goals, the second of which came in the first leg of the fateful European Cup quarter-final tie against Red Star Belgrade. He was killed on 6 February 1958 in the crash at Munich airport after the plane stopped to refuel on the return flight.
In his time at United, he was nicknamed "Snakehips" for his trademark body swerve.
Aged 21 years and 3 months, he was the youngest person of the 23 people to die. An accommodation building at the University of Salford is named after him – the Eddie Colman Court is a block of flats located near the main campus.
A statue of Colman was erected at his graveside in Weaste Cemetery, Weaste, Salford, after his death, but it was badly damaged by vandals within a few years and after being repaired was placed in the home of his father Dick. Dick Colman, who died in October 1986 at the age of 76, is buried alongside Eddie and Eddie's mother Elizabeth, who died in November 1971 at the age of 62.
Twenty-seven workers at a Manchester boxmaking firm had been dismissed from their jobs for leaving work to attend Colman's funeral. However, they were all swiftly reinstated